Fahr's disease

A hereditary condition with autosomal dominant inheritance that is characterized by symmetric calcinosis in the basal ganglia and other brain regions. Patients can either be asymptomatic or show a variety of neuropsychiatric symptoms that include PARKINSONISM; DYSTONIA; TREMOR; ATAXIA; DEMENTIA; PSYCHOSIS; SEIZURES and CHRONIC HEADACHE. Serum levels of CALCIUM; PHOSPHATE; ALKALINE PHOSPHATASE and PARATHYROID HORMONE are normal. Onset is typically between 30 and 50 years of age. A heterozygous mutation in the SLC20A2 gene has been identified. OMIM: 213600

Also Known As:

Adult-onset idiopathic nonarteriosclerotic cerebral calcification; BSPDC Bilateral striopallidodentate calcinosis; Basal Ganglia Calcification, Idiopathic, 1; Bilateral Striopallidodentate Calcinosis; Cerebral Calcification, Nonarteriosclerotic, Idiopathic, Adult-Onset; Cerebrovascular ferrocalcinosis; Fahr's syndrome; Familial idiopathic basal ganglia calcification; Ferrocalcinosis, Cerebrovascular; Fibgc; Idiopathic basal ganglia calcification 1; Striopallidodentate Calcinosis; Striopallidodentate Calcinosis, Autosomal Dominant, Adult-Onset; Striopallidodentate Calcinosis, Bilateral; Striopallidodentate calcinosis, autosomal dominant, adult onset

Nervous System Diseases: 14178
- Neurodegenerative Diseases: 42472
  - Fahr's disease: 86
- Central Nervous System Diseases: 4213
  - Brain Diseases: 15694
    - Basal Ganglia Diseases: 346
      - Fahr's disease: 86
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Calcium Metabolism Disorders: 47
    - Calcinosis: 1855
      - Fahr's disease: 86

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Disease

Drug/Important Bio-Agent (IBA)